反应详情

A mixture of 3-amino-N-phenylbenzamide (2.0 g, 9.4 mmol), diphenylcarbamoyl chloride (2.2 g, 9.4 mmol) and triethylamine (2.6 mL, 19 mmol) in ethanol (10 mL) was heated to reflux for 4.5 hours. The mixture was cooled and concentrated, water was added, the slurry was acidified with 1 N HCl and the solid was collected, washed with water, dried and recrystallized from acetone/hexanes, to give a colorless solid (1.63 g, 42%).

1. temperaturewas heated
2. temperatureto reflux for 4.5 hours
3. temperatureThe mixture was cooled
4. concentrationconcentrated
5. additionwater was added
6. customthe solid was collected
7. washwashed with water
8. customdried
9. customrecrystallized from acetone/hexanes