反应详情

To a solution of N-(2',5'-bistrifluoromethylphenyl)-4-oxa-androstan-3-one-17β-carboxamide. (35 mg, 0.066 mmol, prepared according to the procedures of Example 8) in chlorobenzene (5 mL) was added benzeneseleninic anhydride (30 mg, 0.085 mmol). After stirring the reaction mixture at reflux temperature for overnight, the reaction mixture was diluted with ethyl acetate, washed with brine, dried and concentrated. The residue was purified by prep. tlc (50% EtOAc/hexane). Mass spec. M+ 530(m+1, observed).

1. custom(35 mg, 0.066 mmol, prepared
2. temperatureat reflux temperature for overnight
3. washwashed with brine
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by prep