Methylamine → 3,5,6-Trifluoro-N-methylpyridin-2-amine

Temperature

50 °C

To 10 ml of acetonitrile were added 4.5 g of 2,3,5,6-tetrafluoropyridine and 10 ml of methylamine (10% aqueous solution), and the mixture was stirred at 50° C. for 2 hours. To the solution was added 50 ml of chloroform, and the mixture was washed four times with 250 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the title compound as a pale brown crude oil.

1. washthe mixture was washed four times with 250 ml of distilled water
2. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
3. concentrationconcentrated under reduced pressure

ORD record

ord-2b7df3dfa8d542faa36c98b487ebe739

Source dataset

uspto-grants-1999_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05998436