反应详情

温度

115 °C

To 10 ml of N-methylpyrrolidone were added 6.8 g of 4-(t-butylamino)-2,3,5,6-tetrafluoropyridine together with 7.2 g of benzylamine, and the mixture was stirred at 115° C. for one day and allowed to cool. After adding 40 ml of chloroform, the mixture was washed three times with 400 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain about 8.0 g of the title compound as a dark green crude oil.

1. temperatureto cool
2. washthe mixture was washed three times with 400 ml of distilled water
3. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure