2-Benzylamino-4-(t-butyl)amino-3,5,6-trifluoropyridine → 2-Amino-4-(t-butylamino)-3,5,6-trifluoropyridine

HRID 610193Notes

Reaction equation

HRID 610193 reaction equation
C([NH:8][C:9]1[C:14]([F:15])=[C:13]([NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])[C:12]([F:21])=[C:11]([F:22])[N:10]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:8][C:9]1[C:14]([F:15])=[C:13]([NH:16][C:17]([CH3:18])([CH3:20])[CH3:19])[C:12]([F:21])=[C:11]([F:22])[N:10]=1

Participants

4

Reactant 1

HCID 221212672-Benzylamino-4-(t-butyl)amino-3,5,6-trifluoropyridine

Product 1

HCID 221211632-Amino-4-(t-butylamino)-3,5,6-trifluoropyridine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

To 13 ml of acetic acid were added 4.0 g of the crude 2-benzylamino-4-(t-butyl)amino-3,5,6-trifluoropyridine as described above together with 0.43 g of 10% palladium on carbon, and the mixture was hydrogenated at 60° C. for 6 hours. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure to obtain the title compound as a brown crude oil.

Workup

  1. customThe catalyst was separated by filtration
  2. distillationthe solvent and the like were distilled off under reduced pressure

Sources & evidence

ORD record
ord-f19a85fe3120410184bc338b33828e62
Source dataset
uspto-grants-1999_12
Patent number
US05998436

Reaction notes

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