Tert-Butylamine → HCID 22121211, compound

HRID 610249Notes

Reaction equation

HRID 610249 reaction equation
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([F:10])=[C:4](Cl)[N:3]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13]>C(#N)C>[C:12]([NH:16][C:4]1[N:3]=[C:2]([Cl:1])[C:7]([C:8]#[N:9])=[CH:6][C:5]=1[F:10])([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 27338492,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

Product 1

HCID 22121211HCID 22121211, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 7.6 g of 2,6-dichloro-3-cyano-5-fluoropyridine in 40 ml acetonitrile was added 8.8 g of t-butylamine, and the mixture was stirred overnight at room temperature. The solvent was distilled off the reaction solution. The residue was separated by adding methylene chloride and water. The organic layer was dried over magnesium sulfate, and the solvent was distilled off to obtain 6 g of the title compound as a pale yellow powder.

Workup

  1. distillationThe solvent was distilled off the reaction solution
  2. customThe residue was separated
  3. additionby adding methylene chloride and water
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-715342a9a044477282474ed799a8b8f8
Source dataset
uspto-grants-1999_12
Patent number
US05998436

Reaction notes

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