Benzylamine → HCID 22121254, compound

HRID 610250Notes

Reaction equation

HRID 610250 reaction equation
[C:1]([NH:5][C:6]1[N:11]=[C:10](Cl)[C:9]([C:13]#[N:14])=[CH:8][C:7]=1[F:15])([CH3:4])([CH3:3])[CH3:2].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN1CCCC1=O>[CH2:16]([NH:23][C:10]1[C:9]([C:13]#[N:14])=[CH:8][C:7]([F:15])=[C:6]([NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])[N:11]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22121211HCID 22121211, compound

Product 1

HCID 22121254HCID 22121254, compoundYield 25.4%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
160 °C

Procedure

To 40 ml of N-methylpyrrolidone solution of 6 g 6-t-butylamino-2-chloro-3-cyano-5-fluoropyridine was added 6.3 g of benzylamine, and the mixture was stirred under nitrogen atmosphere at 160° C. for 3 hours and allowed to cool. The reaction solution was separated by adding chloroform and water, and the organic layer was dried over magnesium sulfate, and the solvent was distilled off. The precipitated crystals were collected from the residue by filtration to obtain 2 g of the title compound as a pale yellow powder.

Workup

  1. temperatureto cool
  2. customThe reaction solution was separated
  3. additionby adding chloroform and water
  4. dry with materialthe organic layer was dried over magnesium sulfate
  5. distillationthe solvent was distilled off
  6. filtrationThe precipitated crystals were collected from the residue by filtration

Sources & evidence

ORD record
ord-6b2bc5cb55f04d478010a33885b90b3b
Source dataset
uspto-grants-1999_12
Patent number
US05998436

Reaction notes

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