2-(Bromomethyl)-6-methylpyridine → trans-3-Benzyl-6-(6-methyl-2-pyridyl)methoxy-4-chromanol

HRID 610379Notes

Reaction equation

HRID 610379 reaction equation
[CH2:1]([C@H:8]1[C@H:17]([OH:18])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:19])[CH:15]=2)[O:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[N:23]=1>>[CH2:1]([C@H:8]1[C@H:17]([OH:18])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[N:23]=3)[CH:15]=2)[O:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 125437332-(Bromomethyl)-6-methylpyridineHCID 67592272trans-3-Benzyl-4,6-chromandiol

Product 1

HCID 67591853trans-3-Benzyl-6-(6-methyl-2-pyridyl)methoxy-4-chromanol

Procedure

By the method of Example 5, 500 mg (1.96 mmol) of trans-3-benzyl-4,6-chromandiol and 401 mg of 2-(bromomethyl)-6-methyl pyridine were converted to present title product, purified by flash chromatography on silica gel using 1:1 ethyl acetate:hexane as eluant to yield 0.38 g (53%) of present title product as white crystals, m.p. 87-90° C.

Sources & evidence

ORD record
ord-89db91766ced46b0a2e3193f6c404220
Source dataset
uspto-grants-1999_12
Patent number
US05998451

Reaction notes

Loading…