2-(Bromomethyl)-6-methylpyridine → trans-3-Benzyl-6-(6-methyl-2-pyridyl)methoxy-4-chromanol

Participants

Reaction Steps

By the method of Example 5, 500 mg (1.96 mmol) of trans-3-benzyl-4,6-chromandiol and 401 mg of 2-(bromomethyl)-6-methyl pyridine were converted to present title product, purified by flash chromatography on silica gel using 1:1 ethyl acetate:hexane as eluant to yield 0.38 g (53%) of present title product as white crystals, m.p. 87-90° C.

Provenance & Evidence