Ammonia → 1,3,5-Triazine-2,4-diamine, 6-chloro-

Temperature

0 °C

184.5 g (1.0 mol) of cyanuric chloride was dissolved in 800 mL of acetonitrile at room temperature, and 303.7 g (5.0 mol) of 28%-aqueous ammonia was added dropwise into the solution cooled to 0° C., over 2 hours while vigorously stirring and maintaining the reaction temperature at not more then 10° C. After the completion of dropwise addition, cooling was stopped, and stirring was continued for 1 hour at room temperature, followed by gradually heating to 45° C. and allowing to further react for 4 hours. After cooling, a product was filtered, followed by washing with a large quantity of water. The filtered product was dried at 50° C. in vacuo for 6 hours to obtain 115 g (a yield of 79%) of the above-identified compound.

1. temperaturemaintaining the reaction temperature at not more then 10° C
2. additionAfter the completion of dropwise addition
3. temperaturecooling
4. stirringstirring
5. temperatureby gradually heating to 45° C.
6. customto further react for 4 hours
7. temperatureAfter cooling
8. filtrationa product was filtered
9. washby washing with a large quantity of water
10. customThe filtered product was dried at 50° C. in vacuo for 6 hours
11. customto obtain 115 g (a yield of 79%) of the above-identified compound

ORD record

ord-c7d92b3d395c4f6394a39ec098e973d0

Source dataset

uspto-grants-1999_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05998573