HCID 73099570, compound → D-Arabinose

HRID 610449Notes

Reaction equation

HRID 610449 reaction equation
C(O)[C@@H](O)[C@H:3]([OH:13])[C@@H:4]([OH:12])[C@@H:5]([OH:11])[C@@H:6]([OH:10])[C:7]([O-])=[O:8].O.O.[Na+]>O.O.O.O.O.O.[Co](Cl)Cl.O>[O:8]=[CH:7][C@H:6]([C@@H:5]([C@@H:4]([CH2:3][OH:13])[OH:12])[OH:11])[OH:10]

Participants

4

Reactant 1

HCID 73099570HCID 73099570, compound

Product 1

HCID 66308D-Arabinose

Reagents, catalysts & solvents 2

HCID 517166Dichlorocobalt hexahydrateCatalystHCID 962WaterSolvent

Procedure

Sodium glucoheptonate dihydrate (71.3 g/0.25 mole), cobalt chloride hexahydrate (0.12 g/0.50 mmole) and water (500 ml) are introduced into a double envelope reactor. The mixture is brought to a temperature of 30° C. and to a pH of 6.5 by the addition of soda 2N. The water, oxygenated to 30% (77 ml/0.75 mole), is introduced over 75 minutes, maintaining the temperature between 30 and 35° C. and the pH at 6.5 with the aid of soda 2N. When the addition is finished, the solution is agitated for a further hour. The pH is brought to 2.5 by the addition of concentrated sulphuric acid (8 ml). The pink solution has the following composition:

Workup

  1. additionThe mixture is brought to a temperature of 30° C. and to a pH of 6.5 by the addition of soda 2N
  2. customThe water, oxygenated to 30% (77 ml/0.75 mole)
  3. additionis introduced over 75 minutes
  4. temperaturemaintaining the temperature between 30 and 35° C.
  5. additionWhen the addition
  6. additionThe pH is brought to 2.5 by the addition of concentrated sulphuric acid (8 ml)

Sources & evidence

ORD record
ord-fca1fbc5efb542a6a353ed43df3f54fc
Source dataset
uspto-grants-1999_12
Patent number
US05998608

Reaction notes

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