Butyryl chloride → HCID 11044798, compound

HRID 610493Notes

Reaction equation

HRID 610493 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>>[C:18]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)(=[O:22])[CH2:19][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 8855Butyryl chlorideHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 11044798HCID 11044798, compoundYield 56.3%

Procedure

Beginning with 0.30 gm (1.3 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.165 mL (1.56 mMol) butyryl chloride, 0.22 gm of the title compound were prepared as an ivory foam essentially by the procedure described in Example 4. This residue was crystallized from ethanol:water to provide material for analysis.

Sources & evidence

ORD record
ord-4b8dce2ce7174e9b87bc02903dc577fd
Source dataset
uspto-grants-1999_12
Patent number
US05998622

Reaction notes

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