HCID 10988008, compound → HCID 19601570, compound

HRID 610582Notes

Reaction equation

HRID 610582 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([C:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.Cl.[N:19]1[CH:24]=[CH:23][C:22]([C:25](Cl)=[O:26])=[CH:21][CH:20]=1>>[N:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([C:11]4[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:26])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 10988008HCID 10988008, compoundHCID 12262826Isonicotinoyl chloride hydrochloride

Product 1

HCID 19601570HCID 19601570, compoundYield 61.4%

Procedure

Beginning with 0.200 gm (0.88 mMol) 5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine and 0.188 gm (1.06 mMol) 4-pyridinecarbonyl chloride hydrochloride, 0.180 gm (61%) of the title compound were prepared as an ivory solid essentially by the procedure described in Example 8. An analytical sample was crystallized from aqueous ethanol. m.p.=202.8° C. (dec.) MS(m/e): 333(M+) Calculated for C19H19N5O: Theory: C, 68.45; H, 5.74; N, 21.01. Found: C, 68.28; H, 5.68; N, 21.21.

Sources & evidence

ORD record
ord-65b2d1ab540b44f8ade88b4aee8856ac
Source dataset
uspto-grants-1999_12
Patent number
US05998622

Reaction notes

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