Isopropyl isocyanate → HCID 19601451, compound

HRID 610602Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[CH:18]([N:21]=[C:22]=[O:23])([CH3:20])[CH3:19]>>[CH:18]([NH:21][C:22]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)=[O:23])([CH3:20])[CH3:19]

Participants

Reactant 2

HCID 61277Isopropyl isocyanate

HCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 19601451HCID 19601451, compoundYield 71.2%

Procedure

Beginning with 0.15 gm (0.65 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.077 mL (0.78 mMol) isopropyl isocyanate, 0.146 gm (71%) of the title compound were recovered essentially by the procedure of Example 122. An analytical sample was crystallized from aqueous ethanol. m.p.=217-219° C. (dec.) MS(m/e): 315(M+) Calculated for C17H25N5O: Theory: C, 64.74; H, 7.99; N, 22.20; Found: C, 64.84; H, 8.06; N, 22.44.

Sources & evidence

ORD record: ord-ebd17f542de14f75912c2c6772d9fae2
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05998622

Reaction notes

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