Agidol AF-2 → HCID 135431616, compound

HRID 610676Notes

Reaction equation

HRID 610676 reaction equation
[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][NH:5][CH2:6][CH2:7][NH2:8]>C(O)(C)C>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][NH:5][CH2:6][CH2:7][N:8]=[CH:4][C:3]1[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=1[OH:1]

Participants

3

Reactant 1

HCID 3033857Agidol AF-2

Product 1

HCID 135431616HCID 135431616, compoundYield 156.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

28.7 g of salicylicaldehyde were added to a solution of 39.2 g of N-(2-hydroxybenzyl)-1,2-diaminoethane [prepared in accordance with: A. Bottcher et al., Z. Naturforsch. 49b, 1089-1100 (1994)] in 100 ml of isopropanol, and the resulting solution was refluxed for two hours. Cooling the solution produced a solid, and recrystallization from isopropanol gave 49.8 g of N-(2-hydroxybenzyl)-N'-(2-hydroxybenzylidene)-1,2-diaminoethane.

Workup

  1. customprepared in accordance with: A
  2. temperatureCooling the solution
  3. customproduced
  4. customa solid, and recrystallization from isopropanol

Sources & evidence

ORD record
ord-c866c5b2df084ae0bdf3443fe212f475
Source dataset
uspto-grants-1999_12
Patent number
US05998645

Reaction notes

Loading…