Hydrochloric Acid → 202466-89-5

HRID 610790Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH3:19])[N:15]=[C:14]([NH:20][CH3:21])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:22]>>[ClH:22].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[C:16]([NH:18][CH3:19])[N:15]=[C:14]([NH:20][CH3:21])[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 53121454-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide

Product 1

HCID 17774509202466-89-5Yield 89%

Conditions

Temperature: 0 °C

Procedure

11.5 g (0.0373 mol) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide were treated with 11.5 ml of 25 percent aqueous hydrochloric acid and stirred at 0° C. for 1 hour. The water was evaporated completely and the residue was recrystallized from ethanol/diethyl ether. There were obtained 11.8 g (89%) of 4-amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide hydrochloride (1:1.8) as pale yellow crystals; m.p. 175-250° C. (dec.).

Workup

customThe water was evaporated completely
customthe residue was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record: ord-abc351a37f6e41d093ae84b110f64f78
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05998665

Reaction notes

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