Hydrochloric Acid → HCID 19353539, compound

HRID 610837Notes

Reaction equation

HRID 610837 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([NH:18]C(=O)C)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:5]=[C:4]([CH3:22])[N:3]=1.Cl>[OH-].[Na+]>[NH2:18][C:15]1[CH:16]=[CH:17][C:12]([S:9]([NH:8][C:6]2[CH:5]=[C:4]([CH3:22])[N:3]=[C:2]([Br:1])[CH:7]=2)(=[O:11])=[O:10])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53949666HCID 53949666, compound

Product 1

HCID 19353539HCID 19353539, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1.15 g (0.003 mol) of N-[4-(2-bromo-6-methyl-pyridin-4-ylsulfamoyl)-phenyl]-acetamide were dissolved in 15 ml of 2N NaOH and boiled at reflux for 1 hour. After cooling the mixture was acidified to pH 5 with 2N HCl and the colourless precipitate which separated was filtered off. The material on the suction filter was washed with copious water and dried. There was obtained 0.95 g (93%) of 4-amino-N-(2-bromo-6-methyl-pyridin-4-yl)-benzenesulfonamide as colorless crystals; m.p.: >110° C. (dec.).

Workup

  1. temperatureat reflux for 1 hour
  2. temperatureAfter cooling the mixture
  3. customthe colourless precipitate which separated
  4. filtrationwas filtered off
  5. filtrationThe material on the suction filter
  6. washwas washed with copious water
  7. customdried

Sources & evidence

ORD record
ord-c1b9d9e710d040f19e4361ae5249ba0a
Source dataset
uspto-grants-1999_12
Patent number
US05998665

Reaction notes

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