Hydrochloric Acid → 1-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-6-phenylhexan-1-one hydrochloride

HRID 611089Notes

Reaction equation

HRID 611089 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:26][C:8]2[CH2:9][N:10]([C:13](=[O:25])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:27]>CO>[ClH:27].[CH3:1][N:2]([CH2:4][C:5]1[O:26][C:8]2[CH2:9][N:10]([C:13](=[O:25])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 195999701-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-6-phenylhexan-1-one

Product 1

HCID 195999691-(2-dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-6-phenylhexan-1-one hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

1-(2-Dimethylaminomethyl-5,7-dihydro-4H-furo[2,3-c]pyridin-6-yl)-6-phenylhexan-1-one 0.417 g was dissolved in 2 ml of methanol; hydrogen chloride in methanol was added in excess, followed by stirring. After this mixture was concentrated, diethyl ether was added; the resulting solid was filtered and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationAfter this mixture was concentrated
  2. additiondiethyl ether was added
  3. filtrationthe resulting solid was filtered
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-d8f91e8c20d44256a88613b39c7e1a3b
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

Loading…