Hydrochloric Acid → N,N-dimethyl-[6-(4-phenylbutoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611200Notes

Reaction equation

HRID 611200 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:26][C:8]2[CH2:9][N:10]([C:13]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].[ClH:27]>CO>[ClH:27].[CH3:1][N:2]([CH2:4][C:5]1[O:26][C:8]2[CH2:9][N:10]([C:13]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:14])[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19600063N,N-dimethyl-[6-(4-phenylbutoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine

Product 1

HCID 19600115N,N-dimethyl-[6-(4-phenylbutoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

N,N-Dimethyl-[6-(4-phenylbutoxycarbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.068 g was dissolved in 2 ml of methanol; hydrogen chloride in methanol was added in excess, followed by stirring. After this reaction mixture was concentrated, diethyl ether was added; the resulting solid was filtered and washed with diethyl ether to yield the desired product.

Workup

  1. concentrationAfter this reaction mixture was concentrated
  2. additiondiethyl ether was added
  3. filtrationthe resulting solid was filtered
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-9917b2433b0a48839e8766c00584e995
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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