反应详情

To a suspension of 1.05 g (27.6 mmol) of lithium aluminum hydride in 100 ml of ether, a solution of 3.090 g (18.37 mmol) of ethyl 3-(3-furyl)propionate in 20 ml of ether was added dropwise under ice-cooling, followed by stirring at room temperature for 1 hour. To decompose the excess lithium aluminum hydride, ethyl acetate was added dropwise to the reaction mixture under ice-cooling; subsequently, water was added until a white precipitate formed. The white precipitate was filtered using Celite and washed with ethyl acetate 3 times. The combined filtrate was evaporated under reduced pressure. The obtained crude 3-(3-furyl)propanol was used for the next reaction without purification.

1. temperaturecooling
2. additionwas added dropwise to the reaction mixture under ice-
3. temperaturecooling
4. customformed
5. filtrationThe white precipitate was filtered
6. washwashed with ethyl acetate 3 times
7. customThe combined filtrate was evaporated under reduced pressure