Hydrochloric Acid → 4,5,6,7-Tetrahydrothieno(2,3-c)pyridine--hydrogen chloride (1/1)

HRID 611233Notes

Reaction equation

HRID 611233 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[CH:14]=[CH:15][S:16][C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:17]>CO>[ClH:17].[S:16]1[C:10]2[CH2:9][NH:8][CH2:13][CH2:12][C:11]=2[CH:14]=[CH:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17389936tert-butyl 4,5-Dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate

Product 1

HCID 250673334,5,6,7-Tetrahydrothieno(2,3-c)pyridine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.427 g (5.962 mmol) of 6-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine in 5 ml of methanol, 3 ml of concentrated hydrochloric acid was added, followed by stirring at room temperature for 1 hour. The solvent was distilled off under reduced pressure to yield the desired product.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-c27d3d364d534291bf68b70ab1a0b7bb
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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