Hydrochloric Acid → 6-(4-Phenethylbenzoyl)-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

HRID 611355Notes

Reaction equation

HRID 611355 reaction equation
[CH2:1]([C:9]1[CH:31]=[CH:30][C:12]([C:13]([N:15]2[CH2:20][CH2:19][C:18]3[CH:21]=[C:22]([CH2:24][N:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)[O:23][C:17]=3[CH2:16]2)=[O:14])=[CH:11][CH:10]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[ClH:32]>CO>[ClH:32].[CH2:1]([C:9]1[CH:31]=[CH:30][C:12]([C:13]([N:15]2[CH2:20][CH2:19][C:18]3[CH:21]=[C:22]([CH2:24][N:25]4[CH2:26][CH2:27][CH2:28][CH2:29]4)[O:23][C:17]=3[CH2:16]2)=[O:14])=[CH:11][CH:10]=1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 196000076-(4-Phenethylbenzoyl)-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine

Product 1

HCID 196000886-(4-Phenethylbenzoyl)-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-(4-Phenethylbenzoyl)-2-(1-pyrrolidinylmethyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine 1.004 g was dissolved in 2 ml of methanol; hydrogen chloride in methanol was added in excess, followed by stirring. This mixture was concentrated; the resulting solid was washed with diethyl ether to yield the desired product.

Workup

  1. concentrationThis mixture was concentrated
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-855db7b10e7d46f796e63affd3b0bdd7
Source dataset
uspto-grants-1999_12
Patent number
US05998433

Reaction notes

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