反应详情

A solution of the above crude methyl 2-(2-mesyloxyethyl)furan-3-carboxylate, 0.65 g (6.1 mmol) of benzylamine and 2.33 ml (13.4 mmol) of N,N-diisopropylethylamine in 50 ml of acetonitrile was refluxed for 1 week. The reaction mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1) to yield the desired product.

1. extractionextracted with ethyl acetate 3 times
2. dry with materialThe combined organic layer was dried over anhydrous magnesium sulfate
3. distillationthe solvent was distilled off under reduced pressure
4. customThe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1)