HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl (7-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-chloro-N-(ethoxycarbonylmethyl)anthranilic acid | HCID 11118717 | — |
| Reactant | Potassium cyanate | HCID 11378442 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | Ethyl (7-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate | HCID 9838691 | 87% |
Reaction Steps
Hydrogen chloride is passed into 1 g of 4-chloro-N-(ethoxycarbonylmethyl)anthranilic acid and 1.6 g of potassium cyanate in 20 ml of sulfolane at 50° C. until analysis by HPLC indicates complete conversion. The product is precipitated by addition of water, filtered off, washed with water and dried. 0.95 g (87%) of ethyl 1,2,3,4-tetrahydro-7-chloro-2,4-dioxoquinazolin-1-ylacetate is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06001831 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-7313568f09714fc3a3418ba8d0f60510 |
| Source note | uspto-grants-1999_12 |