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HRID611476

反应详情

EQUATION

反应方程式

HRID 611476 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)CNc1cc(Cl)ccc1C(=O)O
HCID11118717

未命名化合物

结构：N#C[O-].[K+]
HCID11378442

Potassium cyanate

CKNO

PRODUCTS

生成物

1
结构：CCOC(=O)Cn1c(=O)[nH]c(=O)c2ccc(Cl)cc21
HCID9838691

Ethyl (7-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

C12H11ClN2O4

收率 87%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S1(=O)CCCC1
溶剂HCID31347

Sulfolane

C4H8O2S

PROCEDURE

实验过程

Hydrogen chloride is passed into 1 g of 4-chloro-N-(ethoxycarbonylmethyl)anthranilic acid and 1.6 g of potassium cyanate in 20 ml of sulfolane at 50° C. until analysis by HPLC indicates complete conversion. The product is precipitated by addition of water, filtered off, washed with water and dried. 0.95 g (87%) of ethyl 1,2,3,4-tetrahydro-7-chloro-2,4-dioxoquinazolin-1-ylacetate is obtained.

WORKUP

后处理

  1. customThe product is precipitated by addition of water
  2. filtrationfiltered off
  3. washwashed with water
  4. customdried