5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 117727855, compound

HRID 61149Notes

Reaction equation

HRID 61149 reaction equation
NC[C@@H]1[C@H](C)CCCN1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[CH3:25][C:26]1[CH:27]=[CH:28][C:29]([N:35]2[N:39]=[CH:38][CH:37]=[N:36]2)=[C:30]([CH:34]=1)[C:31]([OH:33])=O.[F:40][C:41]1([F:59])[CH2:46][CH2:45][NH:44][CH:43]([CH2:47][N:48]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:42]1>>[NH2:48][CH2:47][CH:43]1[CH2:42][C:41]([F:59])([F:40])[CH2:46][CH2:45][N:44]1[C:31]([C:30]1[CH:34]=[C:26]([CH3:25])[CH:27]=[CH:28][C:29]=1[N:35]1[N:39]=[CH:38][CH:37]=[N:36]1)=[O:33]

Participants

4

Reactant 3

HCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 1177280172-((4,4-Difluoropiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727855HCID 117727855, compound

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid and 2-((4,4-difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione. MS (ESI) 336 (M+H).

Sources & evidence

ORD record
ord-50ccac2f3e294a3e9fbf061a167c3080
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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