Dimethylformamide → HCID 9935888, compound

HRID 611490Notes

Reaction equation

HRID 611490 reaction equation
Br[Si](C)(C)C.C(O[C:9](=[P:40]([OH:42])=[O:41])[C:10]1[N:14]2[C:15]3[C:20]([NH:21][C:22](=[O:23])[C:13]2=[N:12][N:11]=1)=[CH:19][C:18]([C:24]([F:27])([F:26])[F:25])=[C:17]([N:28]1[CH:32]=[C:31]([CH3:33])[N:30]=[C:29]1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH:16]=3)C.CN(C)C=[O:46]>>[CH3:33][C:31]1[N:30]=[C:29]([C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[N:28]([C:17]2[CH:16]=[C:15]3[C:20]([NH:21][C:22](=[O:23])[C:13]4[N:14]3[C:10]([CH2:9][P:40]([OH:41])([OH:42])=[O:46])=[N:11][N:12]=4)=[CH:19][C:18]=2[C:24]([F:25])([F:27])[F:26])[CH:32]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 76113BromotrimethylsilaneHCID 178467663HCID 178467663, compound

Product 1

HCID 9935888HCID 9935888, compound

Procedure

Bromotrimethylsilane (1 ml, 7 mmol) was added dropwise to a stirred solution of 1-(ethoxy-hydroxy-phosphorylmethyl)-8-(4-methyl-2-phenyl-1H-imidazol-1-yl)-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (500 mg, 0.94 mmol) in 20 ml of dry N,N-dimethylformamide.

Sources & evidence

ORD record
ord-f173dc51f167474f9ad6562b646a2dd5
Source dataset
uspto-grants-1999_12
Patent number
US06001832

Reaction notes

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