Isobutyl chloroformate → HCID 131721485, compound

HRID 611496Notes

Reaction equation

HRID 611496 reaction equation
[K+:1].[CH2:2]1[CH2:7][CH2:6][CH:5]([CH:8]2[CH2:13][NH:12][CH2:11][CH2:10][N:9]2[CH2:14][C:15]([O-:17])=[O:16])[CH2:4][CH2:3]1.C(OC(Cl)=O)C(C)C>C(Cl)Cl>[OH2:16].[K+:1].[CH2:2]1[CH2:3][CH2:4][CH:5]([CH:8]2[CH2:13][NH:12][CH2:11][CH2:10][N:9]2[CH2:14][C:15]([O-:17])=[O:16])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 62365Isobutyl chloroformateHCID 131721486HCID 131721486, compound

Product 1

HCID 131721485HCID 131721485, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by first cooling 2-((4-cyclohexyl)piperazin-1-yl)acetic acid potassium salt to a temperature between -8° C. and -15° C. in 5 volumes of anhydrous methylene chloride. To this su e was added isobutyichioroformate at a rate such that the temperature did not exceed -8° C. The resulting reaction mixture was stirred for about 1 hour, the temperature being maintained between -8° C. and -15° C.

Workup

  1. customdid not exceed -8° C
  2. customThe resulting reaction mixture
  3. temperaturethe temperature being maintained between -8° C. and -15° C.

Sources & evidence

ORD record
ord-6df4301862e64270bc824b3517f33a06
Source dataset
uspto-grants-1999_12
Patent number
US06001837

Reaction notes

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