Tert-Butylamine → HCID 19597436, compound

Temperature

20 °C

A solution of tert-butylamine (154 ml) in acetonitrile (100 ml) was added over 10 minutes to a solution of 2-chloro-4'-iodoacetophenone (158.0 g, prepared as described in Organic Magnetic Resonance 12 (12), 1979 pages 691-695) in acetonitrile (700 ml) with stirring under nitrogen at 20° C. The mixture was warmed to 30° C. whereupon a solution was formed, then a slight exotherm occurred and tert-butylamine hydrochloride precipitated. The mixture was kept below 37° C. by occasional cooling. The mixture was left stirring at ambient temperature for 18 hours then filtered and the residue washed with acetonitrile. The combined filtrate and washings were reduced in volume and then taken up in a mixture of ether (700 ml) and water (500 ml). The mixture was stirred while the pH was adjusted to 9 using dilute hydrochloric acid. The mixture was filtered to remove tert-butylamine hydrochloride. The filtrate was acidified with dilute hydrochloric acid to give 4'-iodo-2-(tert-butylamino)acetophenone hydrochloride (102.0 g). This product was reacted with malononitrile (29.9 g) and potassium hydroxide (52.3 g) in methanol (1.5 l) and water (100 ml) in a similar manner to Example 2, to give 2-amino-3-cyano-4-(4-iodophenyl)-1-(tert-butyl)pyrrole (63.2 g), m.p. 166.5-167° C.

1. temperatureThe mixture was warmed to 30° C. whereupon a solution
2. customwas formed
3. customtert-butylamine hydrochloride precipitated
4. customwas kept below 37° C. by occasional cooling
5. waitThe mixture was left
6. stirringstirring at ambient temperature for 18 hours
7. filtrationthen filtered
8. washthe residue washed with acetonitrile
9. additiontaken up in a mixture of ether (700 ml) and water (500 ml)
10. stirringThe mixture was stirred while the pH
11. filtrationThe mixture was filtered
12. customto remove tert-butylamine hydrochloride

ORD record

ord-f507b89f906b4edebc884844000d4211

Source dataset

uspto-grants-1999_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06001839