Hydrochloric Acid → HCID 178433191, compound

HRID 611600Notes

Reaction equation

HRID 611600 reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:11]([N:13]2[CH2:18][CH2:17][CH2:16][CH:15]([C:19]([NH:21][CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])=[O:20])[CH2:14]2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:29]>>[ClH:29].[NH:1]([C:5]1[S:6][C:7]([C:11]([N:13]2[CH2:18][CH2:17][CH2:16][CH:15]([C:19]([NH:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[O:20])[CH2:14]2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178472073HCID 178472073, compound

Product 1

HCID 178433191HCID 178433191, compound

Procedure

103 mg of ethyl (RS)-3-[[1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-3-carbonyl]-amino]-propionate are left to stand at RT in 2.1 ml of 25 percent hydrochloric acid for 6 hrs. The solution is evaporated and the residue is taken up in water and again evaporated. There are obtained 92 mg of (RS)-3-[[1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-3-carbonyl]-amino]-propionic acid hydrochloride (1:2) as a white foam, MS: 383 (M+H)+.

Workup

  1. customThe solution is evaporated
  2. customagain evaporated

Sources & evidence

ORD record
ord-ceeedd3d498b460b9e1f4b8884c948b1
Source dataset
uspto-grants-1999_12
Patent number
US06001855

Reaction notes

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