Trifluoroacetic acid → HCID 178433196, compound

Participants

Reaction Steps

154 mg of tert.-butyl [1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-4-yloxy]-acetate are dissolved in 1.5 ml of dichloromethane and treated with 1.5 ml of trifluoroacetic acid. After 2 hrs. the mixture is evaporated in a vacuum. The residue is dissolved in water and the solution is again evaporated. There are obtained 209 g of mg [1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-4-yloxy]-acetic acid trifluoro- acetate (1:2) as a light hygroscopic foam, MS: 342 (M+H)+.

Provenance & Evidence