Trifluoroacetic acid → HCID 178433196, compound

HRID 611601Notes

Reaction equation

HRID 611601 reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:11]([N:13]2[CH2:18][CH2:17][CH:16]([O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH2:15][CH2:14]2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH:1]([C:5]1[S:6][C:7]([C:11]([N:13]2[CH2:14][CH2:15][CH:16]([O:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:17][CH2:18]2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178433197HCID 178433197, compound

Product 1

HCID 178433196HCID 178433196, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

154 mg of tert.-butyl [1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-4-yloxy]-acetate are dissolved in 1.5 ml of dichloromethane and treated with 1.5 ml of trifluoroacetic acid. After 2 hrs. the mixture is evaporated in a vacuum. The residue is dissolved in water and the solution is again evaporated. There are obtained 209 g of mg [1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-piperidine-4-yloxy]-acetic acid trifluoro- acetate (1:2) as a light hygroscopic foam, MS: 342 (M+H)+.

Workup

  1. customthe mixture is evaporated in a vacuum
  2. dissolutionThe residue is dissolved in water
  3. customthe solution is again evaporated

Sources & evidence

ORD record
ord-9a7da7ce7812420fb622976f33a093e4
Source dataset
uspto-grants-1999_12
Patent number
US06001855

Reaction notes

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