Benzyl isocyanate → HCID 18322998, compound

HRID 611607Notes

Reaction equation

HRID 611607 reaction equation
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[S:13][C:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:15]([CH3:17])[N:16]=1>CN(C=O)C>[CH2:1]([NH:8][C:9](=[O:10])[NH:11][C:12]1[S:13][C:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:15]([CH3:17])[N:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylate

Product 1

HCID 18322998HCID 18322998, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.05 ml of benzyl isocyanate are added to a solution of 5.0 g of ethyl 2-amino-4-methyl-thiazole-5-carboxylate in 50 ml of DMF. The reaction mixture is stirred at RT overnight, evaporated on a rotary evaporator and the residue is suspended in methylene chloride:methanol 1:1. The insoluble material is filtered off and dried. There are obtained 4.6 g of colorless ethyl 2-(3-benzyl-ureido)-4-methyl-thiazole-5-carboxylate, MS: 320 (M+H)+.

Workup

  1. customevaporated on a rotary evaporator
  2. filtrationThe insoluble material is filtered off
  3. customdried

Sources & evidence

ORD record
ord-e9a327e1d7cc48c68c02f70456cd79d5
Source dataset
uspto-grants-1999_12
Patent number
US06001855

Reaction notes

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