Water → (R)-N-(5-(1,2-Dihydroxy-ethyl)-pyrdin-2-yl)-2,2-dimethylpropionamide

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	tert-Butanol	HCID 6386	—
Reactant	Sodium Sulfite	HCID 24437	—
Reactant	2,2-Dimethyl-N-(5-vinylpyridin-2-yl)-propionamide	HCID 21702079	—
Product	(R)-N-(5-(1,2-Dihydroxy-ethyl)-pyrdin-2-yl)-2,2-dimethylpropionamide	HCID 15540846	—

Reaction Conditions

Temperature	5 °C

Reaction Steps

A suspension of AD-Mix-B® (1.40 9) in water (5 ml) and t-butanol (5 ml) was cooled to 5° C. and N-(5-vinyl-pyridin-2-yl)-2,2-dimethylpropionamide (0.204 g, 1.0 mmol) was added. The mixture was stirred at 5° C. for 18 hours. The reaction mixture was then treated with sodium sulfite (3.0 g), stirred for 30 minutes and then extracted with dichloromethane.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06001856
Source dataset	uspto-grants-1999_12
ORD ID	ord-d35b7a7561724eb387e63bbdbd1c7c34
Source note	uspto-grants-1999_12