Hydrochloric Acid → HCID 19598108, compound

HRID 611709Notes

Reaction equation

HRID 611709 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:14][CH3:15])=[C:6]([C:12]=1[Cl:13])[C:7]([O:9]CC)=[O:8].C(O)C.[OH-].[Na+].Cl>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:14][CH3:15])=[C:6]([C:12]=1[Cl:13])[C:7]([OH:9])=[O:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 19598109HCID 19598109, compound

Product 1

HCID 19598108HCID 19598108, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 4A (1.7 g, 5.8 mmol), water (10 ml), ethanol (20 ml) and sodium hydroxide (0.5 g, 12.5 mmol) is heated under reflux with stirring. The reaction mixture is diluted with water (80 ml) and acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.3 g (85%), mp 186-188° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux
  3. filtrationThe solid material is collected by filtration
  4. washwashed with water
  5. customdried
  6. customyielding white crystals, 1.3 g (85%), mp 186-188° C.

Sources & evidence

ORD record
ord-f19f7c15840a4750ae91cf9cf8a89533
Source dataset
uspto-grants-1999_12
Patent number
US06001883

Reaction notes

Loading…