反应详情

O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (1,74 g, 0,01 mol) was dissolved in 40 ml chloroform and 1,09 ml (0,01 mol) phenyl isocyanate was added thereto while stirring. The reaction was monitored by chromatography. After the end of reaction the solution was evaporated and the oily residue was purified by column chromatography. The oil thus obtained was crystallized from diethyl ether. Yield: 0,6 g (20%). Mp: 101-103° C.

1. customAfter the end of reaction the solution
2. customwas evaporated
3. customthe oily residue was purified by column chromatography
4. customThe oil thus obtained
5. customwas crystallized from diethyl ether