Phenyl isocyanate → HCID 19598330, compound

HRID 611763Notes

Reaction equation

HRID 611763 reaction equation
[OH:1][CH:2]([CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)[CH2:3][O:4][NH2:5].[C:13]1([N:19]=[C:20]=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)(Cl)Cl>[C:13]1([NH:19][C:20]([NH:5][O:4][CH2:3][CH:2]([OH:1])[CH2:6][N:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 187662101-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol

Product 1

HCID 19598330HCID 19598330, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (1,74 g, 0,01 mol) was dissolved in 40 ml chloroform and 1,09 ml (0,01 mol) phenyl isocyanate was added thereto while stirring. The reaction was monitored by chromatography. After the end of reaction the solution was evaporated and the oily residue was purified by column chromatography. The oil thus obtained was crystallized from diethyl ether. Yield: 0,6 g (20%). Mp: 101-103° C.

Workup

  1. customAfter the end of reaction the solution
  2. customwas evaporated
  3. customthe oily residue was purified by column chromatography
  4. customThe oil thus obtained
  5. customwas crystallized from diethyl ether

Sources & evidence

ORD record
ord-bcaa123d1a6f41e8a491081e22ef3387
Source dataset
uspto-grants-1999_12
Patent number
US06002002

Reaction notes

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