HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl isocyanate → N-n-hexyl-N'-(2-hydroxy-3-piperidino-propoxy)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl isocyanate | HCID 75659 | — |
| Reactant | 1-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol | HCID 18766210 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-n-hexyl-N'-(2-hydroxy-3-piperidino-propoxy)-urea | HCID 18766211 | — |
Reaction Steps
O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (1,85 g, 0,011 mol) was dissolved in 30 ml chloroform and 1,17 ml (0,011 mol) n-hexyl-isocyanate was added while stirring. After 3 hours the reaction mixture was evaporated and purified by column chromatography. The oil thus obtained crystallizes slowly in refrigerator and rubbing the crystals in petroleum ether a white material was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06002002 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-2bd13eba20b2404897c0e3531e09b796 |
| Source note | uspto-grants-1999_12 |