Benzyl isocyanate → HCID 19598322, compound

HRID 611766Notes

Reaction equation

HRID 611766 reaction equation
[OH:1][CH:2]([CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)[CH2:3][O:4][NH2:5].[CH2:13]([N:20]=[C:21]=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(Cl)(Cl)Cl>[CH2:13]([NH:20][C:21]([NH:5][O:4][CH2:3][CH:2]([OH:1])[CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 187662101-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol

Product 1

HCID 19598322HCID 19598322, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (2,53 g, 0,0145 mol) was dissolved in 40 ml abs. chloroform and 1,8 ml (0,0145 mol) benzyl isocyanate was added thereto while stirring. The mixture was stirred for 2 hours, the solution was evaporated and the residue was crystallized from ethanol-ether mixture. Yield: 2,1 g (47%). Mp.: 100-101° C.

Workup

  1. stirringThe mixture was stirred for 2 hours
  2. customthe solution was evaporated
  3. customthe residue was crystallized from ethanol-ether mixture

Sources & evidence

ORD record
ord-95b48cfbc99a45f98ab4dc31fd79ed96
Source dataset
uspto-grants-1999_12
Patent number
US06002002

Reaction notes

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