tert-Butyl isocyanate → HCID 19598345, compound

HRID 611767Notes

Reaction equation

HRID 611767 reaction equation
[OH:1][CH:2]([CH2:6][N:7]([CH2:10][CH3:11])[CH2:8][CH3:9])[CH2:3][O:4][NH2:5].[C:12]([N:16]=[C:17]=[O:18])([CH3:15])([CH3:14])[CH3:13]>C(Cl)(Cl)Cl>[C:12]([NH:16][C:17]([NH:5][O:4][CH2:3][CH:2]([OH:1])[CH2:6][N:7]([CH2:10][CH3:11])[CH2:8][CH3:9])=[O:18])([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 13273112HCID 13273112, compound

Product 1

HCID 19598345HCID 19598345, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

O-(2-hydroxy-3-diethylamino-propyl)-hydroxylamine was dissolved in 40 ml abs chloroform and 3,08 ml (0,027 mol) tert-butyl isocyanate was added thereto dropwise. The mixture was stirred at room temperature for 15 hours and evaporated. The product thus obtained was purified by column chromatography. The material thus obtained is in oily form which crystallizes when storing in refrigerator. The crystals were filtered after trituration with petroleum ether. Yield: 1,44 g (20%). Mp.: 58-61° C.

Workup

  1. additionwas added
  2. customevaporated
  3. customThe product thus obtained
  4. customwas purified by column chromatography
  5. customThe material thus obtained
  6. customcrystallizes when
  7. filtrationThe crystals were filtered after trituration with petroleum ether

Sources & evidence

ORD record
ord-d02935248c2f422091d3c39d44338e18
Source dataset
uspto-grants-1999_12
Patent number
US06002002

Reaction notes

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