反应详情

O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine (1,74 g, 0,01 mol) was dissolved in 25 ml abs. chloroform and 1,64 g (0,01 mol) 3-nitrophenyl isocyanate in 20 ml abs. chloroform was added thereto while stirring. After 1 hour reaction the mixture was evaporated and purified by column chromatography. The oil thus obtained was crystallized from diethyl ether. Yield: 1,84 g (54%). Mp.: 137-139° C.

1. customAfter 1 hour reaction the mixture
2. customwas evaporated
3. custompurified by column chromatography
4. customThe oil thus obtained
5. customwas crystallized from diethyl ether