反应详情

温度

85 °C

290 g of benzo-1,2,3-thiadiazole-7-carboxylic acid are suspended in 1.6 l of toluene, 3.5 ml of dimethylformamide and 129 ml of thionyl chloride are added and the mixture is stirred at 80-90° C., the suspension turning into a solution as the release of gas progresses. When the reaction has ended, the solution is cooled and filtered over a little Hyflo, the residue is rinsed with toluene and the filtrate is evaporated. 297 g (93%) of crude acid chloride, which can be further reacted directly, result.

1. temperaturethe solution is cooled
2. filtrationfiltered over a little Hyflo
3. washthe residue is rinsed with toluene
4. customthe filtrate is evaporated
5. custom297 g (93%) of crude acid chloride, which can be further reacted directly
6. customresult