Sodium Hydroxide → 2-oxo-1-phenyl-3-Piperidinecarboxylic acid

Participants

Reaction Steps

The product from Step C (0.551 g, 2.56 mmol) was dissolved in methanol (3 mL) and 5% aqueous sodium hydroxide added (3 mL). After 11 h, methanol was removed in vacuo, and the residue partitioned between ethyl acetate and 10% aqueous HCl. The organic layer was washed with saturated brine, and dried over MgSO4. The title compound was obtained as a white solid.

Provenance & Evidence