Phosgene → 2-Methylbenzoyl chloride

HRID 611956Notes

Reaction equation

HRID 611956 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5](C(O)=O)=[CH:6][CH:7]=1.[C:11]([Cl:14])(Cl)=[O:12]>ClC1C=CC=CC=1>[C:2]1([CH3:1])[C:7]([C:11]([Cl:14])=[O:12])=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 7470P-Toluic Acid

Product 1

HCID 702762-Methylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

81.4 g (0.6 mol) of p-toluic acid and 892 g of monochlorobenzene are introduced into the reactor and 582 g (5.9 mol) of phosgene are then added. The set pressure is adjusted to 11.2 bar relative and the reaction medium is heated. The reaction is complete after 3 hours. Analysis of the final reaction medium is carried out by gas chromatography. The level of residual acid is 0.3 mol % and the level of toluoyl chloride obtained is 99.7 mol %.

Workup

  1. additionare then added
  2. temperaturethe reaction medium is heated
  3. customAnalysis of the final reaction medium

Sources & evidence

ORD record
ord-0f9feb7644954d1daeb0ef0bdb554703
Source dataset
uspto-grants-1999_12
Patent number
US06002043

Reaction notes

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