反应详情

A mixture of 14.8 g of 3-carbethoxy-4-chloro-6,7-dimethoxylquinoline, 9.46 g of 3-bromoaniline, 4.05 ml of pyridine, and 150 ml of ethanol was refluxed for 30 min, evaporated to remove ethanol, and partitioned with dichloromethane-aq sodium bicarbonate. The organic layer was washed with water, dried, and concentrated. The residue was recrystallized from ethanol to give a white solid, mp 155-158° C.

1. temperaturewas refluxed for 30 min
2. customevaporated
3. customto remove ethanol
4. custompartitioned with dichloromethane-aq sodium bicarbonate
5. washThe organic layer was washed with water
6. customdried
7. concentrationconcentrated
8. customThe residue was recrystallized from ethanol
9. customto give a white solid, mp 155-158° C.