HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 5328837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | 3-Carbethoxy-4-chloro-6,7-dimethoxylquinoline | HCID 10357178 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 5328837 | HCID 5328837 | — |
Reaction Steps
A mixture of 14.8 g of 3-carbethoxy-4-chloro-6,7-dimethoxylquinoline, 9.46 g of 3-bromoaniline, 4.05 ml of pyridine, and 150 ml of ethanol was refluxed for 30 min, evaporated to remove ethanol, and partitioned with dichloromethane-aq sodium bicarbonate. The organic layer was washed with water, dried, and concentrated. The residue was recrystallized from ethanol to give a white solid, mp 155-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06002008 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-a623c673d8a0494aa4b9b2ed9b8d4cd0 |
| Source note | uspto-grants-1999_12 |