2-Fluoro-5-(trifluoromethyl)pyridine → HCID 117727852, compound

HRID 61201Notes

Reaction equation

HRID 61201 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=1[C:19]1[N:24]=[CH:23][CH:22]=[CH:21][N:20]=1)=[O:11].F[C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=1>>[F:18][C:17]1[CH:16]=[CH:15][CH:14]=[C:13]([C:19]2[N:20]=[CH:21][CH:22]=[CH:23][N:24]=2)[C:12]=1[C:10]([N:4]1[CH2:5][CH2:6][CH2:7][C@@H:8]([CH3:9])[C@H:3]1[CH2:2][NH:1][C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=1)=[O:11]

Participants

3

Reactant 2

HCID 54637542-Fluoro-5-(trifluoromethyl)pyridineHCID 117727763((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone

Product 1

HCID 117727852HCID 117727852, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(6-fluoro-2-(pyrimidin-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 474 [M+1]+. 1H NMR (500 MHz, DMSO-d6) δ 8.90-6.50 (m, 10H), 4.95-2.70 (m, 5H), 2.00-0.65 (m, 8H).

Sources & evidence

ORD record
ord-11c7c639433b42208b2e718a7943efd6
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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