4-Chloro-2-fluoroaniline → 4-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

HRID 612210Notes

Reaction equation

HRID 612210 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]#[N:15].[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1>>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:14]#[N:15])=[C:19]([F:24])[CH:18]=1

Participants

3

Reactant 2

HCID 938984-Chloro-2-fluoroanilineHCID 125594314-Chloro-7-methoxyquinoline-3-carbonitrile

Product 1

HCID 224666624-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

Procedure

In the manner of Example 274 reaction of 4chloro-7-methoxy-3-quinolinecarbonitrile with 4-chloro-2-fluoroaniline gave the title compound as an amber solid, mp 208-210° C.

Sources & evidence

ORD record
ord-3ebc623e443e41b8b861a272e6753e54
Source dataset
uspto-grants-1999_12
Patent number
US06002008

Reaction notes

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