Methanol → 4-methoxybenzyl (6R,7R)-7-amino-3-[(S)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

HRID 612285Notes

Reaction equation

HRID 612285 reaction equation
P(Cl)(Cl)(Cl)(Cl)Cl.C1(CC([NH:16][C@@H:17]2[C:41](=[O:42])[N:19]3[C:20]([C:29]([O:31][CH2:32][C:33]4[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=4)=[O:30])=[C:21]([CH:24]4[CH2:28][CH2:27][CH2:26][O:25]4)[CH2:22][S:23][C@H:18]23)=O)C=CC=CC=1.CN1CCOCC1.CO>ClCCl.O>[NH2:16][C@@H:17]1[C:41](=[O:42])[N:19]2[C:20]([C:29]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)=[O:30])=[C:21]([C@@H:24]3[CH2:28][CH2:27][CH2:26][O:25]3)[CH2:22][S:23][C@H:18]12

Participants

7

Reactant 4

HCID 887MethanolHCID 79724-MethylmorpholineHCID 24819Phosphorus pentachlorideHCID 110057194-methoxybenzyl (6R,7R)-7-phenylacetamido-3-[(RS)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

Product 1

HCID 538410264-methoxybenzyl (6R,7R)-7-amino-3-[(S)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylateYield 38%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent2×

Conditions

Temperature
-10 °C

Procedure

Phosphorus pentachloride (2.15 g, 10.32 mmol) in dichloromethane (108 ml) was added to 4-methoxybenzyl (6R,7R)-7-phenylacetamido-3-[(RS)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate (3.40 g, 6.69 mmol) and N-methylmorpholine (1.50 ml, 13.64 mmol) in dichloromethane (30 ml) at -25° C. The reaction was stirred at -10±5° C. for 45 min., then methanol (14 ml) was added, and stirring continued for 45 min. at room temperature. Water (27 ml) was then added, and the mixture vigorously stirred for a further 1 h. The dichloromethane was evaporated in vacuo, the aqueous residue washed with diethyl ether, then adjusted to pH7 with ammonium hydroxide in the presence of ethyl acetate. The mixture was extracted with ethyl acetate (x2), dried and concentrated in vacuo. The residue was purified by chromatography on silica gel eluting with 50, 70, 80% ethyl acetate in hexane yielding 4-methoxybenzyl (6R,7R)-7-amino-3-[(S)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate (980 mg, 38%) as a yellow foam; νmax (CH2Cl2) 1777, 1721, 1613, 1516, 1152 cm-1 ; δH (CDCl3, 250 MHz) 1.53-1.71 (1 H, m), 1.84-2.02 (4 H, m, 2 exch.), 2.25-2.40 (1 H, m), 3.31 and 3.60 (2 H, ABq, J 18.5 Hz), 3.78-3.98 (2 H, m), 3.81 (3 H, s), 4.72 (1 H, d, J 5.0 Hz), 4.86-4.93 (2 H, m), 5.19 (2 H, s), 6.88 (2 H, d, J 8.6 Hz), 7.33 (2 H, d, J 8.6 Hz). [Mass spectrum: M+ (390)].

Workup

  1. stirringstirring
  2. waitcontinued for 45 min. at room temperature
  3. stirringthe mixture vigorously stirred for a further 1 h
  4. customThe dichloromethane was evaporated in vacuo
  5. washthe aqueous residue washed with diethyl ether
  6. extractionThe mixture was extracted with ethyl acetate (x2)
  7. customdried
  8. concentrationconcentrated in vacuo
  9. customThe residue was purified by chromatography on silica gel eluting with 50, 70, 80% ethyl acetate in hexane

Sources & evidence

ORD record
ord-d30ce34839e84d65a7b84d86e68e64fb
Source dataset
uspto-grants-1999_12
Patent number
US06001997

Reaction notes

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