1,3-Isobenzofurandione, 5-(acetyloxy)- → 5-Hydroxy-2-(4-pyridinylamino)isoindole-1,3-dione hydrochloride

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Reaction Steps

A solution of 5-acetoxyphthalic anhydride (3.03 g), 4-hydrazinopyridine hydrochloride (2.04 g) and glacial acetic acid (15 ml) was heated under reflux, under nitrogen, for 4 hrs, with stirring. The reaction mixture was cooled to ambient temperature, the precipitate was collected, washed with water and dried at 60° C. under vacuum overnight. Trituration with hot absolute ethanol gave 2.3 g (56%) of product, mp >260° C.

Provenance & Evidence