反应详情

A slurry of 3-(3-methoxyphenyl)propionaldehyde (6.46 g), 4-hydrazinopyridine hydrochloride (6.30 g) and magnesium sulfate (5 g) in ethanol (75 ml) was heated under reflux, under nitrogen, with stirring, for 45 mins. The reaction mixture was filtered, the filter cake was washed with ethyl acetate, and the filtrate was concentrated in vacuo. The residue was triturated with ethyl acetate to give 7 g (61%) of product, mp 155-156° C.

1. temperatureunder reflux, under nitrogen
2. filtrationThe reaction mixture was filtered
3. washthe filter cake was washed with ethyl acetate
4. concentrationthe filtrate was concentrated in vacuo
5. customThe residue was triturated with ethyl acetate